Your health provider can help you understand your test results. On average, menopause occurs at age 51. It can also happen abruptly in younger women whose ovaries are removed, resulting in so-called "surgical menopause." And your levels may be low immediately after childbirth and during breastfeeding. You may also experience low estrogen if you have been given certain drugs. TRT seems to be more effective in young men with very low testosterone levels. During puberty, it's normal for levels of estrogen to rise. Menopause is a natural transition for all women in which their estrogen levels go down. Estrogen is a class of related hormones that includes estriol, estradiol, and estrone. Estrogen is often called the female sex hormone, as it plays an important role in the female reproductive system. Around the time of puberty, boys with too little testosterone may also have less than normal strength and endurance, and their arms and legs may continue to grow out of proportion with the rest of their body. Undesirable reactions also occur in women who take anabolic steroids regularly, as a high concentration of testosterone, either natural or manufactured, can cause masculinisation (virilisation) of women. Among women with congenital adrenal hyperplasia, a male-typical play in childhood correlated with reduced satisfaction with the female gender and reduced heterosexual interest in adulthood. For postnatal effects in both males and females, these are mostly dependent on the levels and duration of circulating free testosterone. Since testosterone levels decrease as men age, testosterone is sometimes used in older men to counteract this deficiency. On average, in adult males, levels of testosterone are about seven to eight times as great as in adult females. This binding plays an important role in regulating the transport, tissue delivery, bioactivity, and metabolism of testosterone. As a result, testosterone which is not bound to SHBG is called free testosterone. The part of the total hormone concentration that is not bound to its respective specific carrier protein is the free part. But not all of its uses and purported health benefits are supported by science. From sinus infections and high blood pressure to preventive screening, we’re here for you. Cleveland Clinic’s primary care providers offer lifelong medical care. Due to their possible health risks, it’s important to follow your healthcare provider’s instructions for taking the medication. Most side effects are reversible if you stop taking the drugs, but others may be permanent. High levels of testosterone in female infants may lead to enlargement of their clitoris that can look almost like a penis. Excess testosterone in male children can lead to precocious (early) puberty, which is when puberty begins before the age of nine. At around week seven in utero, the sex-related gene on the Y chromosome initiates the development of the testicles in male infants. Healthcare providers use synthetic testosterone to treat and manage various medical conditions. "Anabolic" refers to muscle building, and "androgenic" refers to increased male sex characteristics. Natural testosterone is a steroid — an anabolic-androgenic steroid. Hone is an online clinic that helps men and women manage their health.