Besides, the phytoestrogen, resveratrolt has received great attention as an upcoming preventive and therapeutic agent against breast cancer . Pterostilbene, a natural methoxylated resveratrol analogue, was first isolated from Pterocarpus santalinus (red sandalwood), a plant used in traditional medicine for diabetes treatment . Piceatannol, with one more hydroxyl group, was already reported as having stronger anti-inflammatory, immunomodulatory, anti-proliferative, anti-leishmanial, anti-leukemic, and protein-tyrosine kinase inhibitory effects . Glycosylated resveratrol analogues have comparable biological effects after transepitelial passage, as they can be hydrolyzed into deglycosylated forms, resveratrol in the intestine . Three glycosylated resveratrol analogues, piceid, piceatannol glucoside, and resveratroloside isolated from the invasive plant species Polygonum cuspidatum were identified as the major antibacterial compounds . Resveratrol is produced in plants by the actions of an enzyme called resveratrol-synthase. Therefore, configuration, substitution, and total hydroxyl groups number substantially influence several mechanisms of antioxidant activity, such as radical scavenging and metal ion chelation abilities. Resveratrol possess many biological properties, but the best described resveratrol property is their capacity to act as a potent antioxidant . Resveratrol possesses a wide range of biological properties, among them antioxidant, cardioprotective, neuroprotective, anti-inflammatory and anticancer activities 19,38. Indeed, resveratrol nanoparticles led to an improvement in its solubility and enhances its antioxidant potential than free form 35,36. In the same line, resveratrol nanoformulation have been conceived as a promising approach for biological function retaining, where polycaprolactone form the hydrophobic core, whereas polyethylene glycol form the hydrophilic shell of the encapsulated resveratrol micelles 33,34. Research has found that resveratrol can protect against high blood pressure, heart disease and insulin resistance. This active compound contains an enzyme called resveratrol-synthase, a natural chemical that protects plant foods against toxins, sun exposure and diseases. In this article we’ll discuss the current research on resveratrol – an active compound found in red wine. It is responsible for promoting muscle growth and strength, as well as improving bone and metabolic health. Life Extension does not provide medical advice, diagnosis, or treatment. Exclusive offers & cutting-edge health content However, they found a better sperm chromatin quality in the RSV treated group than in the control one, although this effect was more evident before freezing rather than after, likely due to the increased ROS production in the last condition. Specifically, the samples were obtained by 10 normozoospermic men and 10 asthenozoospermic patients. In 2020, the Iranian group of Mohammadzadeh and his collaborators published a study that tested the post-thawing effect of RSV directly on spermatozoa separated using the swim-up method . The authors hypothesized that stimulation of AMPK activity by RSV could stabilize the transcripts tested in this study by improving the interaction among mRNAs, making mRNA molecules more resistant to cryopreservation. Opposite results were obtained with Compound C. Therefore, the authors hypothesized that RSV-induced improvement of cryopreserved sperm functions could be mediated through activation of AMPK. The authors showed that RSV significantly increased AMPK phosphorylation and MMP, whereas it decreased ROS and apoptosis-like changes in frozen-thawed spermatozoa. Shabani Nashtaei and co-authors reported that AMPK is expressed in human fresh spermatozoa and it is mainly localized in the post-equatorial region of the sperm head and all along the entire flagellum.
